This section will be updated throughout the project with all our publicly available publications & press releases.
Our ESCAPE-NET Flyer is available here for download.
Here we present publications that are a product of the ESCAPE-NET project.
You can find an overview of the ESCAPE-NET publication on the Zenodo community page for ESCAPE-NET: click here
|Widely used blood pressure drugs might put heart at risk||09-10-2019||Cordis EU research results||Click here|
|Blood pressure drug linked to heart failure||15-05-2019||Cordis EU research results||Click here|
|Commonly used heart drug associated with increased risk of sudden cardiac arrest||17-03-2019||European Society of Cardiology||Click here|
|Gender-based treatment being explored for sudden cardiac arrest||19-03-2018||Health Europa||Click here|
|Project ESCAPE-NET kicks off||17-01-2017||Institut Hospital del Mar d’Investigacions Mèdiques||Click here|
|ESCAPE-NET||21-02-2017||European Resucitation Council||Click here|
|ESCAPE-NET||21-02-2017||European Society of Cardiology / European Heart Rhythm Association||Click here|
|BC Platforms Participates in Horizon 2020 Programme||08-03-2017||BC Platforms LTD Oy||Click here|
|European network created to find sudden cardiac arrest causes and treatments||18-06-2017||European Society of Cardiology / European Heart Rhythm Association||Click here|
Relevant earlier publications
Here we present the most important publications authored by the Consortium partners in the field of Cardiovascular research.
Note that these publications are not a product of the ESCAPE-NET project.
- Alssema M, et al. One risk assessment tool for cardiovascular disease, type 2 diabetes, and chronic kidney disease. Diabetes Care 2012; 35: 741-748. Link: https://www.ncbi.nlm.nih.gov/pubmed/22338109
We developed a nonlaboratory-based risk-assessment tool for identification of people at high cardiometabolic disease risk.
- Dagres N, Hindricks G. Risk stratification after myocardial infarction: is left ventricular ejection fraction enough to prevent sudden cardiac death? Eur Heart J. 2013 Jul;34(26):1964-71.
A paper providing an overview on the significance but also the limitations of a poor heart function as predictor of sudden cardiac death.
- De Hert M et al. Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 2009; 24: 412-424. Link: https://www.ncbi.nlm.nih.gov/pubmed/19682863
A paper providing a statement with the aim of improving the care of patients suffering from severe mental illness.
- Dekker JM et al. Metabolic Syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation 2005; 112: 666-673. Link: https://www.ncbi.nlm.nih.gov/pubmed/16061755
We compared the definitions of the metabolic syndrome proposed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP), World Health Organization (WHO), European Group for the Study of Insulin Resistance (EGIR), and American College of Endocrinology (ACE) with respect to the prevalence of the metabolic syndrome and the association with 10-year risk of fatal and nonfatal CVD.
- Dekker JM et al. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes. The ARIC Study. Circulation 2000; 102: 1239-1244.
We aimed to study the predictive value of heart rate-corrected QT interval (QTc) for incident coronary heart disease (CHD) and cardiovascular disease (CVD) mortality in the black and white general population, and to validate various QT measurements.
- Fouche PF, Carlson JN, The importance of comorbidity and illness severity scores in cardiac arrest research Resuscitation. 2016 May;102:e3. doi: 10.1016/j.resuscitation.2016.01.035. Epub 2016 Mar 17. Link: http://dx.doi.org/10.1016/j.resuscitation.2016.01.035
It is just recently that comorbidity has been included as a prognostic factor in cardiac arrest research. The inclusion of data on comorbidity in cardiac arrest research could increase the quality of all cardiac arrest research and also tell us more about the presumed etiology of the cardiac arrest.
- He M et al. Combining multiple ECG features does not improve prediction of defibrillation outcome compared to single features in a large population of out-of-hospital cardiac arrests. Crit Care. 2015 Dec 10;19(1):425 Link: https://www.ncbi.nlm.nih.gov/pubmed/26652159
Quantitative electrocardiographic (ECG) waveform analysis provides a noninvasive reflection of the metabolic milieu of the myocardium during resuscitation and is a potentially useful tool to optimize the defibrillation strategy.
- Ottani F et al. Cyclosporine A in Reperfused Myocardial Infarction: The Multicenter, Controlled, Open-Label CYCLE Trial. J Am Coll Cardiol. 2016 Feb 2;67(4):365-74. Link: https://www.ncbi.nlm.nih.gov/pubmed/26821623
Whether cyclosporine A (CsA) has beneficial effects in reperfused myocardial infarction (MI) is debated. This study investigated whether CsA improved ST-segment resolution in a randomized, multicenter phase II study.
- Priori SG et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015 Nov 1;36(41):2793-867. Link: https://www.ncbi.nlm.nih.gov/pubmed/26320108
These are the European guidelines for prevention of sudden cardiac death. The ESC issues guidelines for medical practice covering all fields of cardiovascular medicine.
- Raatikainen MJ et al. Access to and clinical use of cardiac implantable electronic devices and interventional electrophysiological procedures in the European Society of Cardiology Countries: 2016 Report from the European Heart Rhythm Association. Europace. 2016 Aug;18 Suppl 3:iii1-iii79. Link: https://www.escardio.org/static_file/Escardio/Subspecialty/EHRA/Publications/Documents/EHRA%20WB%20EP%20Supplement%202016.pdf
A report about the utilization of resources and procedures, including implantation of cardiac devices for prevention of sudden cardiac death, performed in the different countries in Europe.
- Ringh M et al., Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med 2015; 372:2316-2325June 11, 2015 DOI: 10.1056/NEJMoa1406038Link: http://www.nejm.org/doi/full/10.1056/NEJMoa1406038
The dispatch of laypersons to sudden cardiac arrest has been shown to increase the bystander CPR-rates. To measure potential increase in survival there is always a problem of sufficient sample size. To date there is no study that has proven these applications successful in increasing survival.
- Ristagno G et al. Azienda Regionale Emergenza Urgenza (AREU) Research Group. Amplitude Spectrum Area to Guide Defibrillation: A Validation on 1617 Ventricular Fibrillation Patients. Circulation 2015;131(5):478-87 Link: https://www.ncbi.nlm.nih.gov/pubmed/25466976
This study sought to validate the ability of amplitude spectrum area (AMSA) to predict defibrillation success and long-term survival in a large population of out-of-hospital cardiac arrests.
- Ristagno G et al. Early Activation of the Kynurenine Pathway Predicts Early Death and Long-term Outcome in Patients Resuscitated From Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2014 Aug 4;3(4). pii: e001094 Link: https://www.ncbi.nlm.nih.gov/pubmed/25092787
The kynurenine pathway (KP) is the major route of tryptophan (TRP) catabolism and is activated by inflammation and after cardiac arrest in animals. We hypothesized that the KP activation level correlates with severity of post-cardiac arrest shock, early death, and long-term outcome.
- Ristagno G et al. Amplitude spectrum area to guide resuscitation – A retrospective analysis during out-of-hospital cardiopulmonary resuscitation in 609 patients with ventricular fibrillation cardiac arrest. Resuscitation 2013; 84(12):1697-703 Link: https://www.ncbi.nlm.nih.gov/pubmed/24005007
The capability of amplitude spectrum area (AMSA) to predict the success of defibrillation (DF) was retrospectively evaluated in a large database of out-of-hospital cardiac arrests.
- van der Heijden AA et al. Risk of a Recurrent Cardiovascular Event in Individuals With Type 2 Diabetes or Intermediate Hyperglycemia: The Hoorn Study. Diabetes Care. 2013;36:3498-502. Link: https://www.ncbi.nlm.nih.gov/pubmed/23877981
A paper to investigate risk of a recurrent cardiovascular event and its predictors in a population-based cohort.
- van der Heijden AA et al. Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: accuracy of the Framingham, SCORE and UKPDS risk functions. The Hoorn Study. Diabetes Care. 2009;32:2094-8. Link: https://www.ncbi.nlm.nih.gov/pubmed/19875606
A paper to test the validity of the Framingham, Systematic Coronary Risk Evaluation (SCORE), and UK Prospective Diabetes Study (UKPDS) risk function in the prediction of riskof coronary heart disease (CHD) in populations with normal glucose tolerance (NGT), intermediate hyperglycemia, and type 2 diabetes.
- Wells DM, et al., Socioeconomic status and survival from ventricular fibrillation out-of-hospital cardiac arrest, Annals of Epidemiology (2016), http://dx.doi.org/10.1016/j.annepidem.2016.04.001
The role of socioeconomic status in cardiac arrest has been studied before. There is however a lack of high quality data.